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College

College of Science and Engineering

Major

Biology

Faculty Mentor

Glenn Yasuda, PhD

Faculty Editor

Daniel Smith, PhD

Student Editor

Jollan Franco

Abstract

Chronic wound formation is an affliction that disproportionately affects those of lower socioeconomic status on a global scale due to a variety of contributing factors, like type 2 diabetes and housing environment (Fayne, 2020). Antibiotic use in response to a cutaneous wound selects for antibiotic-resistant bacteria, posing a risk for colonization by biofilm-forming species that can result in chronic wounds. Biofilms decrease future antibiotic use efficiency and inflames the surrounding tissue, potentially resulting in necrosis of the tissues. Current studies show the possibility for probiotic application or reintroduction of commensal organisms erased by antibiotic use as a therapeutic mechanism for cutaneous wounds. Here, a two-step cutaneous wound treatment protocol is proposed involving antibiotic use and subsequent bacteriotherapy as a preventative measure for chronic wound formation via antibiotic-resistant bacteria.

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