Progress Towards Synthesis of Acyclic Hydrazide-based Nucleoside Mimics as Potential Antiviral Drug Candidates
Faculty Information
Joseph Langenhan | Course: CHEM 4990 | Project-in-progress
Presentation Type
Individual
Presentation Format
Poster
Start Date
10-5-2024 12:00 PM
End Date
10-5-2024 1:00 PM
Abstract or artist statement
Nucleoside analogs are a valuable source of potential antiviral drugs. For example, the nucleoside AZT is a well-known drug used to treat HIV infections and molnupiravir is approved to treat SARS-CoV-2 infections. Simple acyclic nucleoside analogs like ganciclovir have also been employed in the clinic as antivirals. We report here the synthesis of a novel class of acyclic hydrazide-based nucleoside mimics which will be evaluated for possible antiviral activity.
Keywords: Synthetic organic chemistry for developing antiviral molecules
Progress Towards Synthesis of Acyclic Hydrazide-based Nucleoside Mimics as Potential Antiviral Drug Candidates
Nucleoside analogs are a valuable source of potential antiviral drugs. For example, the nucleoside AZT is a well-known drug used to treat HIV infections and molnupiravir is approved to treat SARS-CoV-2 infections. Simple acyclic nucleoside analogs like ganciclovir have also been employed in the clinic as antivirals. We report here the synthesis of a novel class of acyclic hydrazide-based nucleoside mimics which will be evaluated for possible antiviral activity.
Keywords: Synthetic organic chemistry for developing antiviral molecules