Document Type

Article

Publication Date

2026

Abstract

Acute limb ischemia (ALI) represents an abrupt decrease in arterial perfusion that endangers life and limb viability. This pathology is rarely seen in younger populations with no significant comorbidities such as peripheral arterial disease or diabetes. One uncommon cause of ALI includes hypercoagulable states from acquired or inherited thrombophilias such as antiphospholipid syndrome and Protein C & S deficiency. This report examines a case of Rutherford 2A acute limb ischemia in a 45-year-old male patient who presented with paresthesia and worsening pain in his right lower extremity. Due to the emergent nature of ALI, swift diagnosis and prompt revascularization to prevent amputation or death is vital in cases of atypical presentation. Further, hypercoagulable states in the setting of ALI are associated with increased rates of re-intervention and limb loss, making a definitive diagnosis of thrombophilia necessary to establish a proper standard of care and avoid adverse outcomes in the post-operative period.

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